NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Emerson Hyndman (torn ACL)
- OUT: Amar Sejdic (muscle)
- QUESTIONABLE: Franco Ibarra (lower body)
- QUESTIONABLE: Ronald Hernandez (fitness)
- QUESTIONABLE: Josef Martinez (knee soreness)
Austin FC
- OUT: Ulises Segura (left knee)
- OUT: Ben Sweat (ACL)
- OUT: Aaron Schoenfeld (left knee)
- OUT: Danny Hoesen (left hip)
- OUT: Matt Besler (concussion)
- OUT: Kenneth Kronholm (right knee)
- OUT: Francisco Calvo (right thigh)
- OUT: Brian Gutierrez (right ankle)
- OUT: Maikel van der Werff (sports hernia)
- QUESTIONABLE: Joe Gyau (achilles)
Colorado Rapids
- OUT: None
- OUT: Aidan Morris (left knee)
- OUT: Artur (right hip)
- OUT: Perry Kitchen (left knee)
- OUT: Kevin Molino (right knee)
- OUT: Waylon Francis (health & safety protocols)
- OUT: Pedro Santos (concussion)
- QUESTIONABLE: Milton Valenzuela (right thigh)
- QUESTIONABLE: Lucas Zelarayan (left hip)
FC Dallas
- OUT: Beni Redžić (ankle sprain)
- OUT: Johnny Nelson (back surgery)
- OUT: Ryan Hollingshead (foot)
- QUESTIONABLE: Jimmy Maurer (thigh)
D.C. United
- OUT: Brendan Hines-Ike (hip)
- OUT: Adrian Perez (foot)
- OUT: Chris Odoi-Atsem (quad)
- QUESTIONABLE: Nigel Robertha (groin)
- QUESTIONABLE: Bill Hamid (hamstring)
Houston Dynamo FC
- OUT: Nico Lemoine (right groin)
- OUT: Adam Lundkvist (lower body)
- QUESTIONABLE: Adalberto Carrasquilla (lower body)
- QUESTIONABLE: Marko Maric (left leg)
- QUESTIONABLE: Corey Baird (lower body)
- QUESTIONABLE: Tyler Pasher (lower body)
- OUT: Mahala Opoku (left knee)
- OUT: Pablo Sisniega (nose)
- OUT: Eduard Atuesta (right ankle)
- OUT: Eddie Segura (right knee)
- OUT: Erik Duenas (left knee)
- OUT: Carlos Vela (right quad)
- OUT: Julian Gaines (pelvic stress fracture)
- OUT: Alvaro Quezada (chest)
- OUT: Tristan Blackmon (left adductor)
- QUESTIONABLE: Derrick Williams (undisclosed)
- QUESTIONABLE: Jonathan Bond (undisclosed)
Inter Miami CF
- OUT: Ian Fray (undisclosed injury)
- OUT: Joevin Jones (undisclosed injury)
- OUT: Ventura Alvarado (undisclosed injury)
- OUT: Victor Ulloa (undisclosed injury)
- OUT: Ryan Shawcross (undisclosed injury)
Minnesota United FC
- OUT: Justin McMaster (thigh)
- OUT: Jan Gregus (undisclosed)
- QUESTIONABLE: Hassani Dotson (undisclosed)
CF Montréal
- OUT: Robert Thorkelsson (adductor)
- OUT: Mason Toye (shoulder)
- OUT: Kiki Struna (calf)
Nashville SC
- OUT: None
New England Revolution
- QUESTIONABLE: Carles Gil (muscular)
- QUESTIONABLE: Maciel (undisclosed)
- QUESTIONABLE: Jon Bell (undisclosed)
- QUESTIONABLE: Gustavo Bou (undisclosed)
- QUESTIONABLE: Edward Kizza (undisclosed)
- QUESTIONABLE: Emmanuel Boateng (undisclosed)
New York City FC
- OUT: None
New York Red Bulls
- OUT: Aaron Long (Achilles)
- OUT: Lucas Monzon (hamstring)
Orlando City SC
- OUT: Alexandre Pato (lower body)
- OUT: Mason Stajduhar (surgical recovery)
- OUT: Joey DeZart (lower body)
- QUESTIONABLE: Sebastian Mendez (lower body)
- QUESTIONABLE: Chris Mueller (lower body)
- QUESTIONABLE: Uri Rosell (lower body)
Philadelphia Union
- OUT: Ilsinho (hamstring)
- OUT: Cory Burke (ankle)
- QUESTIONABLE: Alejandro Bedoya (calf)
Portland Timbers
- OUT: Ismaila Jome (left Achilles tendon surgery)
- OUT: Jeff Attinella (season ending right rectus femoris surgery)
- OUT: Andy Polo (season ending right quad and knee surgery)
- OUT: Eryk Williamson (left ACL tear)
Real Salt Lake
- OUT: Zack Farnsworth (undisclosed)
- OUT: Marcelo Silva (undisclosed)
- OUT: Bobby Wood (undisclosed)
- OUT: Jeremy Ebobisse (concussion)
- QUESTIONABLE: Shea Salinas (undisclosed)
- QUESTIONABLE: Siad Haji
Seattle Sounders FC
- OUT: Jordan Morris (ACL injury)
- OUT: Jordy Delem (right ACL tear)
Sporting Kansas City
- OUT: Felipe Hernandez (personal reasons)
- OUT: Jaylin Lindsey (hamstring)
- QUESTIONABLE: Alan Pulido (knee)
Toronto FC
- OUT: Ayo Akinola (torn ACL)
- OUT: Jozy Altidore (lower body)
- OUT: Ralph Priso (lower body)
- OUT: Alejandro Pozuelo (lower body)
- OUT: Tsubasa Endoh (lower body)
- OUT: Jayden Nelson (health & safety protocols)
- OUT: Nick DeLeon (health & safety protocols)
Vancouver Whitecaps FC
- OUT: Caio Alexandre (left foot, fifth metatarsal fracture
- OUT: Cristian Gutierrez (left quad strain)
- OUT: Erik Godoy (right foot)
