NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Ozzie Alonso (leg)
- OUT: Machop Chol (leg)
- QUESTIONABLE: Brad Guzan (illness)
Austin FC
- OUT: Zan Kolmanic (right ACL)
- QUESTIONABLE: Gyasi Zardes (left calf tightness)
- OUT: Vinicius Mello (right lower leg)
- OUT: Ben Bender (left knee)
- OUT: Chris Mueller (right upper leg)
- OUT: Victor Bezerra (right lower leg)
- OUT: Federico Navarro (left lower leg)
- OUT: Mauricio Pineda (right lower leg)
- QUESTIONABLE: Rafael Czichos (left upper leg)
- QUESTIONABLE: Brian Gutierrez (left lower leg)
- OUT: Stiven Jimenez (lower leg fracture)
- OUT: Arquimides Ordoñez (leg)
Colorado Rapids
- OUT: Alex Gersbach (adductor tendon surgery)
- OUT: Aboubacar Keita (lower body)
- OUT: Jack Price (Achilles)
- OUT: William Yarbrough (knee surgery)
- OUT: Max (removed from team activities
- QUESTIONABLE: Sidnei Tavares (illness)
- OUT: Will Sands (knee)
FC Dallas
- OUT: Geovane Jesus (right knee)
- OUT: Tarik Scott (season-ending injury)
- OUT Sebastian Lletget (hamstring)
D.C. United
- OUT: Martin Rodriguez (knee)
- OUT: Mohanad Jeahze (ankle)
- OUT: Tyler Miller (shoulder)
Houston Dynamo FC
- OUT: Ifunanyachi Achara (knee)
- OUT: Tate Schmitt (knee)
- QUESTIONABLE: Amine Bassi (lower body)
- OUT: None
- OUT: Gaston Brugman (torn meniscus, left knee)
- OUT: Calegari (knee)
- OUT: Javier "Chicharito" Hernandez (torn ACL, right knee)
- OUT: Martin Caceres (avulsion fracture, left knee)
- OUT: Jalen Neal (sports hernia surgery)
- OUT: Chris Mavinga (groin)
- QUESTIONABLE: Riqui Puig (ankle)
Inter Miami CF
- OUT: Ian Fray (ACL)
- OUT: Gregore (Lisfranc)
- OUT: Franco Negri (ACL)
- OUT: Corentin Jean (ACL)
Minnesota United FC
- OUT: Ryen Jiba (knee)
- OUT: Robin Lod (knee)
- OUT: Joseph Rosales (thigh)
- OUT: Brent Kallman (knee)
- OUT: Aaron Herrera (ankle)
- OUT: Robert Thorkelsson (adductor)
- QUESTIONABLE: Jules-Anthony Vilsaint (ankle)
Nashville SC
- OUT: Nick DePuy (lower body)
- QUESTIONABLE: Lukas MacNaughton (lower body)
- OUT: Dylan Borrero (left knee season ending)
- OUT: Brandon Bye (right ACL season ending)
- OUT: Henry Kessler (right hamstring)
- OUT: Maciel (left Achilles)
- OUT: Damian Rivera (right knee)
- QUESTIONABLE: Gustavo Bou (right leg)
New York City FC
- OUT: Maxi Moralez (ACL)
New York Red Bulls
- OUT: Serge Ngoma (hamstring)
- OUT: Lewis Morgan (hip)
- OUT: Dante Vanzeir (back)
- QUESTIONABLE: Steven Sserwadda (knee)
Orlando City SC
- OUT: Adam Grinwis (left thigh)
- OUT: Favian Loyola (left arm)
- QUESTIONABLE: Antonio Carlos (right lower leg)
Philadelphia Union
- OUT: Leon Flach (core)
- QUESTIONABLE: Jakob Glesnes (core)
- QUESTIONABLE: Jose Martinez (knee)
- QUESTIONABLE: Julian Carranza (concussion protocol)
Portland Timbers
- OUT: David Ayala (left knee)
- OUT: Jaroslaw Niezgoda (right knee)
- OUT: Eryk Williamson (right knee)
- OUT: Diego Chara (abdomen)
- QUESTIONABLE: Yimmi Chara (left hamstring)
- QUESTIONABLE: Evander (right calf)
Real Salt Lake
- OUT: Erik Holt (shoulder)
- OUT: Pablo Ruiz (knee)
- OUT: Jasper Löffelsend (ankle)
- OUT: Nathan (ACL)
- QUESTIONABLE: Jack Skahan (lower body)
Seattle Sounders FC
- OUT: Kelyn Rowe (right quad strain)
- QUESTIONABLE: Cristian Roldan (concussion protocol)
- QUESTIONABLE: Cody Baker (concussion protocol)
Sporting Kansas City
- OUT: Kortne Ford (Achilles surgery)
- OUT: Kayden Pierre (hamstring)
- QUESTIONABLE: Tim Leibold (groin)
- QUESTIONABLE: Alan Pulido (quad contusion)
- OUT: Lucas Bartlett (shoulder)
- OUT: Miguel Perez (ankle)
- QUESTIONABLE: Rasmus Alm (groin)
Toronto FC
- OUT: Adama Diomande (lower body)
- OUT: Lorenzo Insigne (lower body)
- OUT: Sean Johnson (hand surgery)
- OUT: Raoul Petretta (back spasms)
- OUT: Greg Ranjitsingh (knee surgery)
- OUT: Brandon Servania (lower body)
Vancouver Whitecaps FC
- OUT: Thomas Hasal (patellar tendinopathy)
- QUESTIONABLE: Luis Martins (left calf strain)
- QUESTIONABLE: Ryan Gauld (left foot contusion)
