NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Dylan Castanheira (Achilles)
- OUT: Machop Chol (leg)
- OUT: Ozzie Alonso (ACL)
- OUT: Brad Guzan (Achilles)
- OUT: Miles Robinson (Achilles)
- QUESTIONABLE: Josef Martinez (knee)
- QUESTIONABLE: Santiago Sosa (abductor)
- QUESTIONABLE: Caleb Wiley (lower body)
Austin FC
- OUT: Frederik Kleemann (left knee)
- OUT: Vinicius Mello (left foot surgery)
- OUT: Chris Hegardt (left knee surgery)
- OUT: Adam Armour (left knee surgery)
- OUT: Yordy Reyna (left thigh)
- OUT: Pablo Sisniega (concussion)
- QUESTIONABLE: Christian Fuchs (right thigh)
- OUT: Spencer Richey (head)
- OUT: Javier Casas (pelvis)
- QUESTIONABLE: Rafael Czichos (right lower leg)
- QUESTIONABLE: Kacper Przybylko (back)
- QUESTIONABLE: Jairo Torres (left hip)
- OUT: Isaac Atanga (leg)
- OUT: Allan Cruz (leg)
- OUT: Calvin Harris (leg)
- OUT: Alec Kann (lower body)
- OUT: Ronald Matarrita (ankle surgery)
Colorado Rapids
- OUT: Braian Galván (right knee)
- OUT: Aboubacar Keita (torn ACL right knee)
- OUT: Oliver Larraz (right leg)
- QUESTIONABLE: Jack Price (hamstring)
- OUT: Kevin Molino (right knee)
- QUESTIONABLE: Marlon Hairston (right thigh)
FC Dallas
- OUT: Alan Velasco (health and safety protocols)
D.C. United
- OUT: Adrien Perez (foot)
- OUT: Moses Nyeman (thigh)
- OUT: Chris Odoi-Atsem (ankle)
- OUT: Andy Najar (thigh)
- OUT: Gaoussou Samake (thigh)
- QUESTIONABLE: Russell Canouse (thigh)
Houston Dynamo FC
- OUT: None
- OUT: Eddie Segura (right knee)
- OUT: Erik Dueñas (left knee)
- OUT: Julian Gaines (pelvis)
- OUT: Ryan Hollingshead (knee)
- OUT: Latif Blessing (right knee/ankle)
- QUESTIONABLE: Ismael Tajouri-Shradi (left quad)
- QUESTIONABLE: Franco Escobar (left calf)
- OUT: Adam Saldaña (left ankle)
- OUT: Jorge Villafaña (left knee)
- OUT: Sacha Kljestan (hip)
- QUESTIONABLE: Eriq Zavaleta (upper leg)
Inter Miami CF
- OUT: Ian Fray (right ACL)
- OUT: Joevin Jones (undisclosed)
- OUT: Nick Marsman (undisclosed)
- OUT: Victor Ulloa (undisclosed)
- OUT: Robbie Robinson (undisclosed)
- OUT: Ryan Sailor (undisclosed)
- QUESTIONABLE: Damion Lowe (undisclosed)
- QUESTIONABLE: Edison Azcona (undisclosed)
- QUESTIONABLE: Bryce Duke (undisclosed)
- QUESTIONABLE: Kieran Gibbs (undisclosed)
Minnesota United FC
- OUT: Hassani Dotson (knee)
- OUT: Patrick Weah (knee)
- OUT: Romain Métanire (thigh)
- OUT: Niko Hansen (thigh)
- OUT: Justin McMaster (shoulder)
CF Montréal
- OUT: Tomas Giraldo (hamstring)
- OUT: Bjorn Johnsen (foot)
- OUT: Mason Toye (adductor)
Nashville SC
- OUT: Teal Bunbury (right knee)
- OUT: Robert Castellanos (right ankle surgery)
- OUT: Irakoze Donasiyano (left thigh)
- OUT: Randall Leal (ankle)
- QUESTIONABLE: Gustavo Bou (upper leg)
- QUESTIONABLE: Jozy Altidore (lower leg)
New York City FC
- OUT: Anton Tinnerholm (Achilles Tendon)
- OUT: Kevin O'Toole (head)
- QUESTIONABLE: Chris Gloster (lower body)
- QUESTIONABLE: Tayvon Gray (lower body)
- QUESTIONABLE: Maxi Moralez (lower body)
- QUESTIONABLE: Malte Amundsen (lower body)
New York Red Bulls
- OUT: Andres Reyes (foot)
- OUT: Wikelman Carmona (foot)
- OUT: Lucas Monzón (hamstring)
- OUT: Ashley Fletcher (knee)
- OUT: Serge Ngoma (hamstring)
- OUT: John Tolkin (health & safety protocols)
Orlando City SC
- OUT: Antonio Carlos (left thigh)
- OUT: Silvester van der Water (left lower leg)
- OUT: Benji Michel (right lower leg)
Philadelphia Union
- QUESTIONABLE: Mikael Uhre (quad)
Portland Timbers
- OUT: Blake Bodily (hamstring)
- OUT: Claudio Bravo (thigh)
- OUT: George Fochive (hip)
- OUT: Diego Gutierrez (foot)
- OUT: Tega Ikoba (health and safety protocols)
- OUT: Felipe Mora (knee surgery)
- OUT: Jaroslaw Niezgoda (thigh)
- OUT: Hunter Sulte (health and safety protocols)
- OUT: Justin vom Steeg (health and safety protocols)
Real Salt Lake
- OUT: Zack Farnsworth (right ankle)
- OUT: Bret Halsey (ankle)
- OUT: Eric Holt (left foot)
- OUT: Jonathan Menéndez (adductor)
- OUT: Damir Kreilach (back)
- OUT: Anderson Julio (hamstring)
- OUT: George Asomani (left ankle)
- OUT: Gilbert Fuentes (personal)
- OUT: Nathan (health & safety protocols)
- QUESTIONABLE: Siad Haji (right adductor)
- QUESTIONABLE: Marcos Lopez (left pelvis)
Seattle Sounders FC
- OUT: João Paulo (right ACL tear)
Sporting Kansas City
- OUT: Gadi Kinda (knee surgery)
- OUT: Alan Pulido (knee surgery)
- OUT: Ozzie Cisneros (hamstring)
- QUESTIONABLE: Nicolas Isimat-Mirin (facial injury & concussion)
- QUESTIONABLE: Graham Zusi (thigh)
- QUESTIONABLE: Johnny Russell (knee)
- QUESTIONABLE: Khiry Shelton (hamstring)
- QUESTIONABLE: Nikola Vujnovic (calf)
Toronto FC
- OUT: Kadin Chung (lower body)
- OUT: Jahkeele Marshall-Rutty (lower body)
- OUT: Chris Mavinga (lower body)
- OUT: Noble Okello (lower body)
- QUESTIONABLE: Jonathan Osorio (lower body)
- QUESTIONABLE: Alejandro Pozuelo (lower body)
- QUESTIONABLE: Jacob Shaffelburg (lower body)
Vancouver Whitecaps FC
- OUT: Caio Alexandre (left hand fracture)
- OUT: Tristan Blackmon (right knee sprain)
- OUT: Thomas Hasal (left hand)
- OUT: Isaac Boehmer (health & safety protocols)
- OUT: Cody Cropper (health & safety protocols)
- OUT: Pedro Vite (health & safety protocols)
